祁旸凡，苏州大学青年特聘教授，硕士生导师。研究领域为分子细胞生物学与肿瘤医学转化，重点关注RNA-RNA 结合蛋白调控网络在肿瘤进展中的功能和作用机制。发表论文总他引超过600次，其中以第一/共同通讯作者在Nature Communications, Signal Transduction and Targeted Therapy, eLife, BBA-Molecular Basis of Disease等杂志发表SCI论文。先后主持国家自然科学基金青年项目、辽宁省科技厅面上项目和辽宁省教育厅科研项目等多个省市级基金项目，参加国家优秀青年科学基金项目、国家自然科学基金重大研究计划培育项目和国家自然科学基金重点项目。
研究内容与发现：
1.挖掘致病性的RNA异常剪接事件和剪接调控因子。
2.非编码RNA的在肿瘤中功能与分子机理研究。
3.应激压力与细胞分子调控网络。
邮箱：925705868@qq.com； 电话: 18900962087
代表性研究论文(2021年-2024年）：
1 Chen Lei, Zhang Wenjing, Chen Dan, Yang Quan, Sun Su, et al., Wang Yang*, Yangfan Qi*. RBM4dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibitingLKB1-AMPK-axis [J]. Signal Transduction and Targeted Therapy. 2023 Apr 21;8(1):159. (IF=39.3; Q1/1 区; 第一通讯)
2 Fang Huang, Zhenwei Dai, Jinmiao Yu, Kainan Wang, et al, Yangfan Qi*, Yang Wang*. RBM7deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway [J]. eLife. 2024 Feb 23. (IF=7.7; Q1 /1 区;共同通讯）
3 Chaogun Chen, Fang Huang, Xiaojie Li, Lin Liu, et al, Yangfan Qi*, Yang Wang*. Identification ofsplicing factors sienature predicting prognosis risk and the mechanistic roles of novel oncogenes in HNSCC [J]. BBA-MOL BASIS DIS. 2024 Apr;1870(4):167115. (IF=6.2; Q1 /2 区; 共同通讯)
4 Lu Bai, Siwen Sun, Wenmei Su, Chaoqun Chen,Yuesheng Lv, Jinrui Zhang, Jinyao Zhao, Man Li. Yangfan Qi*, Wenjing Zhang*, and Yang Wang*. Melatonin inhibits HCC progression through regulating the alternative splicing of NEMO. Frontiers in Pharmacology, 2022,13:1007006. (IF=6.0; Q1/2 区; 共同通讯)
5 SiSi Li, Yangfan Qi, JiaChuan Yu, YuChao Hao, Bin He. et al. Nuclear Aurora kinase A switchesm6A reader YTHDCl to enhance an oncogenic RNA splicing of tumor suppressor RBM41. Signal Transduction and Targeted Therapy, 2022, 7(1). (IF=38.1; Q1/1 区; 共同一作)
6 Yangfan Qi, Wei Han, Dan Chen, Jinyao Zhao, Lu Bai, Fang Huang, et al., Yang Wang. Engineering circular RNA regulators to specifically promote circular RNA production1. Theranostics, 2021, 11(15)7322-7336. (IF:11.556; Q1/1 区;共同一作)
7 Yangfan Qi, Jing Yu, Wei Han, Xiaojuan Fan, Haili Qian, et al., Yang Wang, Zefeng Wang. A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation[J].Nature Communications,2016,7:ncomms11840. (IF=12.298; Q1/1区;共同一作)
8 Zhang w*, Sun Y*, Bai L*, Zhi L*, Yang Y, Zhao Q, Chen C, Qi Y, Gao W, He W, Wang L, et al., Wang Y*. RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. The Journal of Clinical Investigation. 2021 Nov 15;131(22):e152067. (1F=19.476; Q1/1 区; 共同作者)
9 Jinrui Zhang, Ge Zhang, Wenjing Zhang, et al, Lili Zhi, Yangfan Qi, JinyaoZhao, Quentin Liu, Han Liu, Yang Wang*. Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer. Cell Death and Differentiation.2022 Nov;29(11):2247-2261.(IF=12.4; Q1/1 区; 共同作者)
10 Yu Sun, Dan Chen, Siwen Sun, et al, Qingzhi Zhao, Yangfan Qi, Jinrui Zhang, Ge Zhang, Han Liu, Qingkai Yang, Quentin Liu, Yang Wang,* and Wenjing Zhang*. RBMS1 Coordinates with the m6A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation. Advanced Science.2024, 11, 2307122. (IF=14.3; Q1/1 区; 共同作者)
招生信息：
硕士研究生；专业为生物学或基础医学；学术型。
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