石鹏 副教授

石鹏,青年特聘教授,硕士生导师。2021年于北京大学获得博士学位,2021年-2024年在北京大学基础医学院进行博士后训练。主要利用超分辨成像、电镜成像、活细胞成像等方法研究细胞骨架-线粒体互作、细胞能量代谢,并阐明其在细胞迁移和肿瘤侵袭转移中的作用。相关研究成果以第一作者/通讯作者在Nature Communications, PNAS, EMBO Reports, Journal of Cell Science等杂志发表。获得国家自然科学基金青年项目,博士后面上项目及北大-清华生命科学联合中心杰出博士后项目资助。应邀担任医学分子生物学杂志青年编委,Nature Communications等杂志的审稿人。


邮箱:pengshi@suda.edu.cn      电话:0512-65880886

通讯地址:苏州市工业园区仁爱路199号苏州大学403幢3120室


研究方向:

1. 受限性细胞迁移调控机制与肿瘤转移;

2. 肿瘤转移过程中的细胞衰老相关研究;

3.细胞骨架-线粒体互作机制研究。


代表性研究论文(*共同第一作者 #共同通讯作者):

1. Yan Wang*, Peng Shi*,#, Geyao Liu, Wei Chen, Ya-Jun Wang,Yiping Hu, Ao Yang, Tonghua Wei, Yu-Chen Chen, Ling Liang, Zheng Liu, Yan-Jun Liu, Congying Wu#, (2025) Espin enhances confined cell migration by promoting filopodia formation and contributes to cancer metastasis. EMBO Rep.

2. Shi, P.*, X. Ren*, J. Meng, C*. Kang, Y. Wu, Y. Rong, S. Zhao, Z. Jiang, L. Liang, W. He, Y. Yin, X. Li, Y. Liu, X. Huang, Y. Sun, B. Li, and C. Wu. (2022). Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS. Nat Commun.

3. Ren, X. *, Shi, P.*,#, Su, J., Wei, T., Li, J., Hu, Y., and Wu, C#,. (2024). Loss of Myo19 increases metastasis by enhancing microenvironmental ROS gradient and chemotaxis. EMBO Rep.

4. CHEN, M.*, PAN, H.*, SUN, L.*, SHI, P.*, ZHANG, Y., LI, L., HUANG, Y., CHEN, J., JIANG, P., FANG, X., WU, C. & CHEN, Z. (2020) Structure and regulation of human epithelial cell transforming 2 protein. Proc Natl Acad Sci.

5. SHI, P.*, WANG, Y.*, HUANG, Y., ZHANG, C., LI, Y., LIU, Y., LI, T., WANG, W., LIANG, X. & WU, C. (2019) Arp2/3-branched actin regulates microtubule acetylation levels and affects mitochondrial distribution. J Cell Sci.

6. Wu, Y., Ren, X., Shi, P., and Wu, C. (2023). Regulation of mitochondrial structure by the actin cytoskeleton. Cytoskeleton.

7. QIN, J., GUO, Y., XUE, B., SHI, P., CHEN, Y., SU, Q. P., HAO, H., ZHAO, S., WU, C., YU, L., LI, D. & SUN, Y. (2020) ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation. Nat Commun.

8. Rong, Y., Yang, W., Hao, H., Wang, W., Lin, S., Shi, P., Huang, Y., Li, B., Sun, Y., Liu, Z., et al. (2021). The Golgi microtubules regulate single cell durotaxis. EMBO Rep


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